Gene Variant Detail

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Gene KDR
Variant R275L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions KDR (VEGFR2) R275L lies within the Ig-like C2-type domain 3 of the Kdr (Vegfr2) protein (UniProt.org). R275L has been identified in sequencing studies (PMID: 16959974, PMID: 26009992), but has not been biochemically characterized and therefore, its effect on Kdr (Vegfr2) protein function is unknown (PubMed, Jul 2020).
Associated Drug Resistance

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Transcript NM_002253
gDNA chr4:g.55113456C>A
cDNA c.824G>T
Protein p.R275L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002253 chr4:g.55113456C>A c.824G>T p.R275L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
KDR R275L unknown