Gene Variant Detail

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Gene ATM
Variant S1905Ifs*25
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions ATM S1905Ifs*25 indicates a shift in the reading frame starting at amino acid 1905 and terminating 25 residues downstream causing a premature truncation of the 3056 amino acid Atm protein (UniProt.org). S1905Ifs*25 has not been characterized, however, based on the effects of other truncation mutations downstream of S1905 (PMID: 16603769), is predicted to lead to a loss of Atm protein function.
Associated Drug Resistance
Category Variants Paths

ATM mutant ATM inact mut ATM S1905Ifs*25

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Transcript NM_000051.3
gDNA chr11:g.108307934dupA
cDNA c.5712dupA
Protein p.S1905Ifs*25
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001351834.1 chr11:g.108307934dupA c.5712dupA p.S1905Ifs*25 RefSeq GRCh38/hg38
XM_011542840.3 chr11:g.108307934dupA c.5712dupA p.S1905Ifs*25 RefSeq GRCh38/hg38
NM_000051.3 chr11:g.108307934dupA c.5712dupA p.S1905Ifs*25 RefSeq GRCh38/hg38
XM_006718843.4 chr11:g.108307934dupA c.5712dupA p.S1905Ifs*25 RefSeq GRCh38/hg38
XM_017017790.2 chr11:g.108307934dupA c.5712dupA p.S1905Ifs*25 RefSeq GRCh38/hg38
XM_017017789.2 chr11:g.108307934dupA c.5712dupA p.S1905Ifs*25 RefSeq GRCh38/hg38
XM_005271562.5 chr11:g.108307934dupA c.5712dupA p.S1905Ifs*25 RefSeq GRCh38/hg38
XM_011542843.2 chr11:g.108307934dupA c.5712dupA p.S1905Ifs*25 RefSeq GRCh38/hg38
XM_017017791.1 chr11:g.108307934dupA c.5712dupA p.S1905Ifs*25 RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM S1905Ifs*25 gallbladder carcinoma predicted - sensitive Olaparib Case Reports/Case Series Actionable In a clinical case study, treatment with Lynparza (olaparib) resulted in improved clinical symptoms and progression-free survival of 13 months in a patient with gallbladder carcinoma harboring ATM S1905Ifs*25 (PMID: 32045060). 32045060