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Gene APC
Variant E1374K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions APC E1374K lies within the beta-catenin binding and downregulation region of the Apc protein (PMID: 14672538). E1374K has been identified in sequencing studies (PMID: 27311873, PMID: 26725423), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Feb 2023).
Associated Drug Resistance
Category Variants Paths

APC mutant APC E1374K

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Transcript NM_000038.5
gDNA chr5:g.112839714G>A
cDNA c.4120G>A
Protein p.E1374K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000038 chr5:g.112839714G>A c.4120G>A p.E1374K RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112839714G>A c.4120G>A p.E1374K RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112839714G>A c.4120G>A p.E1374K RefSeq GRCh38/hg38
NM_001127510 chr5:g.112839714G>A c.4120G>A p.E1374K RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112839714G>A c.4120G>A p.E1374K RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries