Gene Variant Detail

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Gene NTRK2
Variant A203T
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions NTRK2 A203T lies within Ig-like C2-type domain 1 of the Ntrk2 protein (UniProt.org). A203T results in increased cell surface expression and receptor dimerization of Ntrk2, and leads to increased phosphorylation of Ntrk2, Akt, and Erk, and IL3-independent growth in culture (PMID: 32315394).
Associated Drug Resistance
Category Variants Paths

NTRK2 mutant NTRK2 act mut NTRK2 A203T

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Transcript NM_001018064.3
gDNA chr9:g.84723596G>A
cDNA c.607G>A
Protein p.A203T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001369537.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014760.2 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014752.2 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001018066.3 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_005252001.4 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_005252004.3 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_005252006.4 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014751.2 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_011518718.3 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001007097.2 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_005252003.4 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001369546.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_011518720.3 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001018066.2 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001018065.2 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001369542.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_011518718.4 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014755.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001369540.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014751.3 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014755.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014758.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001369548.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014753.2 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_006180.4 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001018064.2 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_005252001.3 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014759.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001369544.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_005252007.4 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_005252003.3 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014754.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001369539.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001369549.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001369534.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001291937.2 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014756.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014761.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_047423432.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001369532.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001369538.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001018064.3 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001291937.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014752.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_047423433.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001369541.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014760.3 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_005252004.2 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_006180.6 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014753.3 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001369545.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001369547.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001369533.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001018065.2 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001007097.3 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
XM_017014757.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38
NM_001369543.1 chr9:g.84723596G>A c.607G>A p.A203T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK2 A203T hematologic cancer sensitive Entrectinib Preclinical - Cell culture Actionable In a preclinical study, Rozlytrek (entrectinib) decreased Ntrk2 phosphorylation and viability and increased apoptosis in a transformed cell line expressing NTRK2 A203T in culture (PMID: 32315394). 32315394
NTRK2 A203T hematologic cancer sensitive Foretinib Preclinical - Cell culture Actionable In a preclinical study, Foretinib (GSK1363089) inhibited viability of transformed cells expressing NTRK2 A203T in culture (PMID: 32315394). 32315394
NTRK2 A203T hematologic cancer sensitive Cabozantinib Preclinical - Cell culture Actionable In a preclinical study, Cometriq (Cabometyx, cabozantinib) inhibited viability of transformed cells expressing NTRK2 A203T in culture (PMID: 32315394). 32315394
NTRK2 A203T hematologic cancer sensitive Crizotinib Preclinical - Cell culture Actionable In a preclinical study, Xalkori (crizotinib) inhibited viability of transformed cells expressing NTRK2 A203T in culture (PMID: 32315394). 32315394
NTRK2 A203T hematologic cancer sensitive Crenolanib Preclinical - Cell culture Actionable In a preclinical study, Crenolanib (CP-868596) inhibited viability of transformed cells expressing NTRK2 A203T in culture (PMID: 32315394). 32315394
NTRK2 A203T hematologic cancer sensitive Ponatinib Preclinical - Cell culture Actionable In a preclinical study, Iclusig (ponatinib) inhibited viability of transformed cells expressing NTRK2 A203T in culture (PMID: 32315394). 32315394
NTRK2 A203T hematologic cancer sensitive Larotrectinib Preclinical - Cell culture Actionable In a preclinical study, Vitrakvi (larotrectinib) inhibited viability of transformed cells expressing NTRK2 A203T in culture (PMID: 32315394). 32315394