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Gene FLT3
Variant E604_F605insSPRGGNEYFYVDFREYEYDLKWE
Impact List insertion
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 E604_F605insSPRGGNEYFYVDFREYEYDLKWE results in the insertion of 23 amino acids in the juxtamembrane domain of the Flt3 protein between amino acids 604 and 605 (PMID: 14759363). E604_F605insSPRGGNEYFYVDFREYEYDLKWE has not been biochemically characterized, but can be predicted to lead to activation of Flt3 based on the effects of other Flt3 internal tandem duplication (ITD) mutations (PMID: 12970773, PMID: 9737679, PMID: 11090077).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 exon 14 ins FLT3 E604_F605insSPRGGNEYFYVDFREYEYDLKWE

FLT3 mutant FLT3 exon14 FLT3 exon 14 ins FLT3 E604_F605insSPRGGNEYFYVDFREYEYDLKWE

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Transcript NM_004119.3
gDNA chr13:g.28034112_28034113insCTTAAGGTCATACTCATACTCCCTAAAGTCTACATAAAAATACTCGTTACCACCCCTAGGGCTCTCCCA
cDNA c.1812_1813insAGCCCTAGGGGTGGTAACGAGTATTTTTATGTAGACTTTAGGGAGTATGAGTATGACCTTAAGTGGGAG
Protein p.E604_F605insSPRGGNEYFYVDFREYEYDLKWE
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28034112_28034113insCTTAAGGTCATACTCATACTCCCTAAAGTCTACATAAAAATACTCGTTACCACCCCTAGGGCTCTCCCA c.1812_1813insAGCCCTAGGGGTGGTAACGAGTATTTTTATGTAGACTTTAGGGAGTATGAGTATGACCTTAAGTGGGAG p.E604_F605insSPRGGNEYFYVDFREYEYDLKWE RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28034112_28034113insCTTAAGGTCATACTCATACTCCCTAAAGTCTACATAAAAATACTCGTTACCACCCCTAGGGCTCTCCCA c.1812_1813insAGCCCTAGGGGTGGTAACGAGTATTTTTATGTAGACTTTAGGGAGTATGAGTATGACCTTAAGTGGGAG p.E604_F605insSPRGGNEYFYVDFREYEYDLKWE RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References