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Gene IDH1
Variant R119P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions IDH1 R119P does not lie within any known functional domains of the Idh1 protein (UniProt.org). R119P has been associated with acquired IDH1 inhibitor resistance with IDH1 R132C/L (PMID: 32380538), but has not been biochemically characterized and therefore, its effect on Idh1 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance Y
Category Variants Paths

IDH1 mutant IDH1 R119P

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Transcript NM_005896.4
gDNA chr2:g.208248427C>G
cDNA c.356G>C
Protein p.R119P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001282386.1 chr2:g.208248427C>G c.356G>C p.R119P RefSeq GRCh38/hg38
NM_001282387.1 chr2:g.208248427C>G c.356G>C p.R119P RefSeq GRCh38/hg38
NM_005896.3 chr2:g.208248427C>G c.356G>C p.R119P RefSeq GRCh38/hg38
NM_001282387.1 chr2:g.208248427C>G c.356G>C p.R119P RefSeq GRCh38/hg38
NM_005896.4 chr2:g.208248427C>G c.356G>C p.R119P RefSeq GRCh38/hg38
NM_001282386.1 chr2:g.208248427C>G c.356G>C p.R119P RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 R119P IDH1 R132S acute myeloid leukemia predicted - resistant Ivosidenib Case Reports/Case Series Actionable In a Phase I trial, IDH1 R119P was identified at progression in a patient with acute myeloid leukemia harboring IDH1 R132S who previously responded to Tibsovo (ivosidenib) treatment (PMID: 32380538; NCT02074839). 32380538
IDH1 R119P IDH1 R132L IDH2 R140Q acute myeloid leukemia predicted - resistant Ivosidenib Case Reports/Case Series Actionable In a Phase I trial, IDH1 R119P and IDH2 R140Q were identified at progression in a patient with acute myeloid leukemia harboring IDH1 R132L who previously responded to Tibsovo (ivosidenib) treatment (PMID: 32380538; NCT02074839). 32380538
IDH1 R119P IDH1 R132L acute myeloid leukemia predicted - resistant Ivosidenib Case Reports/Case Series Actionable In a Phase I trial, IDH1 R119P was identified at progression in a patient with acute myeloid leukemia harboring IDH1 R132L who previously had a response of stable disease with Tibsovo (ivosidenib) treatment (PMID: 32380538; NCT02074839). 32380538