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Gene FBXW7
Variant S546P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FBXW7 S546P lies within WD repeat 5 of the Fbxw7 protein (UniProt.org).  S546P has not been characterized in the scientific literature and therefore, its effect on Fbxw7 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 S546P

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Transcript NM_033632.3
gDNA chr4:g.152326014A>G
cDNA c.1636T>C
Protein p.S546P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_033632.3 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152326014A>G c.1636T>C p.S546P RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References