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Gene | ERBB4 |
Variant | S774R |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | ERBB4 S774R lies within the protein kinase domain of the Erbb4 protein (UniProt.org). S774R has been identified in sequencing studies (PMID: 23525077, PMID: 29316426), but has not been biochemically characterized and therefore, its effect on Erbb4 protein function is unknown (PubMed, Mar 2024). |
Associated Drug Resistance | |
Category Variants Paths |
ERBB4 mutant ERBB4 S774R |
Transcript | NM_005235.3 |
gDNA | chr2:g.211562068A>C |
cDNA | c.2322T>G |
Protein | p.S774R |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001042599.1 | chr2:g.211562068A>C | c.2322T>G | p.S774R | RefSeq | GRCh38/hg38 |
NM_005235.2 | chr2:g.211562068A>C | c.2322T>G | p.S774R | RefSeq | GRCh38/hg38 |
NM_001042599.1 | chr2:g.211562068A>C | c.2322T>G | p.S774R | RefSeq | GRCh38/hg38 |
NM_005235.3 | chr2:g.211562068A>C | c.2322T>G | p.S774R | RefSeq | GRCh38/hg38 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
ERBB4 S774R | unknown |