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Gene FLT3
Variant Y572del
Impact List deletion
Protein Effect gain of function
Gene Variant Descriptions FLT3 Y572del results in the deletion of an amino acid in the juxtamembrane domain of the Flt3 protein at amino acid 572 (PMID: 14759363). Y572del confers a gain of function to the Flt3 protein as demonstrated by activation of Stat5, Akt, and Erk1/2 signaling and IL3-independent growth in cultured cells (PMID: 33914060).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 Y572del

FLT3 mutant FLT3 exon14 FLT3 Y572del

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Transcript NM_004119.2
gDNA chr13:g.28034203_28034205delATA
cDNA c.1714_1716delTAT
Protein p.Y572del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017020488.1 chr13:g.28015649_28015651delTAG c.1714_1716delTAC p.Y572delY RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28034203_28034205delATA c.1714_1716delTAT p.Y572del RefSeq GRCh38/hg38
XM_011535015.2 chr13:g.28034147_28034149delTAG c.1714_1716delTAC p.Y572delY RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 Y572del hematologic cancer sensitive Midostaurin Preclinical - Cell culture Actionable In a preclinical study, Rydapt (midostaurin) decreased proliferation in transformed cells expressing FLT3 Y572del in culture (PMID: 33914060). 33914060
FLT3 Y572del hematologic cancer sensitive Quizartinib Preclinical - Cell culture Actionable In a preclinical study, Vanflyta (quizartinib) decreased proliferation in transformed cells expressing FLT3 Y572del in culture (PMID: 33914060). 33914060
FLT3 Y572del hematologic cancer sensitive Lestaurtinib Preclinical - Cell culture Actionable In a preclinical study, Lestaurtinib (CEP-701) decreased proliferation in transformed cells expressing FLT3 Y572del in culture (PMID: 33914060). 33914060
FLT3 Y572del hematologic cancer sensitive Sorafenib Preclinical - Cell culture Actionable In a preclinical study, Nexavar (sorafenib) decreased proliferation in transformed cells expressing FLT3 Y572del in culture (PMID: 33914060). 33914060
FLT3 Y572del hematologic cancer sensitive Crenolanib Preclinical - Cell culture Actionable In a preclinical study, Crenolanib (CP-868596) decreased proliferation in transformed cells expressing FLT3 Y572del in culture (PMID: 33914060). 33914060
FLT3 Y572del hematologic cancer sensitive Ponatinib Preclinical - Cell culture Actionable In a preclinical study, Iclusig (ponatinib) decreased proliferation in transformed cells expressing FLT3 Y572del in culture (PMID: 33914060). 33914060