Gene Variant Detail

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Gene RET
Variant G810N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET G810N lies within the protein kinase domain of the Ret protein (UniProt.org). G810N has been associated with acquired resistance to RET inhibitors (PMID: 38127829), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET G810N

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Transcript NM_020975.6
gDNA chr10:g.43119566_43119567delGGinsAA
cDNA c.2428_2429delGGinsAA
Protein p.G810N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43119566_43119567delGGinsAA c.2428_2429delGGinsAA p.G810N RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43119566_43119567delGGinsAA c.2428_2429delGGinsAA p.G810N RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43119566_43119567delGGinsAA c.2428_2429delGGinsAA p.G810N RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43119566_43119567delGGinsAA c.2428_2429delGGinsAA p.G810N RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43119566_43119567delGGinsAA c.2428_2429delGGinsAA p.G810N RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43119566_43119567delGGinsAA c.2428_2429delGGinsAA p.G810N RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References