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Gene | FBXW7 |
Variant | R465S |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | FBXW7 R465S lies within WD repeat domain 3 of the Fbxw7 protein (UniProt.org). R465S has been identified in the scientific literature (Blood (2022) 140 (Supplement 1): 12293–12294), but has not been biochemically characterized and therefore, its effect on Fbxw7 protein function is unknown (PubMed, Mar 2024). |
Associated Drug Resistance | |
Category Variants Paths |
FBXW7 mutant FBXW7 R465S |
Transcript | NM_033632.3 |
gDNA | chr4:g.152328233G>T |
cDNA | c.1393C>A |
Protein | p.R465S |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_033632.3 | chr4:g.152328233G>T | c.1393C>A | p.R465S | RefSeq | GRCh38/hg38 |
XM_011532084.3 | chr4:g.152328233G>T | c.1393C>A | p.R465S | RefSeq | GRCh38/hg38 |
XM_047415900.1 | chr4:g.152328233G>T | c.1393C>A | p.R465S | RefSeq | GRCh38/hg38 |
XM_024454123.2 | chr4:g.152328233G>T | c.1393C>A | p.R465S | RefSeq | GRCh38/hg38 |
XM_011532085.3 | chr4:g.152328233G>T | c.1393C>A | p.R465S | RefSeq | GRCh38/hg38 |
NM_001349798.2 | chr4:g.152328233G>T | c.1393C>A | p.R465S | RefSeq | GRCh38/hg38 |
XM_047415897.1 | chr4:g.152328233G>T | c.1393C>A | p.R465S | RefSeq | GRCh38/hg38 |
XM_047415898.1 | chr4:g.152328233G>T | c.1393C>A | p.R465S | RefSeq | GRCh38/hg38 |
XM_047415899.1 | chr4:g.152328233G>T | c.1393C>A | p.R465S | RefSeq | GRCh38/hg38 |
XM_047415901.1 | chr4:g.152328233G>T | c.1393C>A | p.R465S | RefSeq | GRCh38/hg38 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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