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Gene | NTRK2 |
Variant | F633L |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | NTRK2 F633L (corresponds to F617L in the canonical isoform) lies within the protein kinase domain of the Ntrk2 protein (UniProt.org). F633L has not been characterized in the scientific literature and therefore, its effect on Ntrk2 protein function is unknown (PubMed, Jul 2024). |
Associated Drug Resistance | |
Category Variants Paths |
NTRK2 mutant NTRK2 F633L |
Transcript | NM_006180.6 |
gDNA | chr9:g.84948594T>C |
cDNA | c.1897T>C |
Protein | p.F633L |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_005252003.4 | chr9:g.84948594T>C | c.1897T>C | p.F633L | RefSeq | GRCh38/hg38 |
XM_047423432.1 | chr9:g.84948594T>C | c.1897T>C | p.F633L | RefSeq | GRCh38/hg38 |
XM_005252001.4 | chr9:g.84948594T>C | c.1897T>C | p.F633L | RefSeq | GRCh38/hg38 |
XM_017014751.3 | chr9:g.84948594T>C | c.1897T>C | p.F633L | RefSeq | GRCh38/hg38 |
XM_047423433.1 | chr9:g.84948594T>C | c.1897T>C | p.F633L | RefSeq | GRCh38/hg38 |
XM_005252004.3 | chr9:g.84948594T>C | c.1897T>C | p.F633L | RefSeq | GRCh38/hg38 |
NM_006180.6 | chr9:g.84948594T>C | c.1897T>C | p.F633L | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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