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Gene FBXW7
Variant E117del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions FBXW7 E117del results in the deletion of an amino acid in the Fbxw7 protein at amino acid 117 (UniProt.org). E117del has been identified in sequencing studies (PMID: 35770320, PMID: 27284958, PMID: 29134647), but has not been biochemically characterized and therefore, its effect on Fbxw7 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 E117del

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Transcript NM_033632.3
gDNA chr4:g.152411465_152411467delCTC
cDNA c.349_351delGAG
Protein p.E117del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_024454122.1 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
NM_033632 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_017008362 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
NM_001257069 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_011532083 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
NM_001257069.1 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_011532084 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_011532085 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152411465_152411467delCTC c.349_351delGAG p.E117del RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References