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Gene FBXW7
Variant G422C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FBXW7 G422C lies within WD repeat 2 of the Fbxw7 protein (UniProt.org). G422C has not been characterized in the scientific literature and therefore, its effect on Fbxw7 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 G422C

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Transcript NM_033632.3
gDNA chr4:g.152328362C>A
cDNA c.1264G>T
Protein p.G422C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011532085 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_011532083 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_017008362 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_011532084 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
NM_033632 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152328362C>A c.1264G>T p.G422C RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References