Gene Variant Detail

Gene FBXW7
Variant G579W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FBXW7 G579W lies between WD repeats 5 and 6 of the Fbxw7 protein (UniProt.org). G579W has been identified in the scientific literature studies (PMID: 24755471, PMID: 27399335), but has not been biochemically characterized and therefore, its effect on Fbxw7 protein function is unknown (PubMed, Nov 2018).
Associated Drug Resistance

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Transcript NM_033632
gDNA chr4:g.152324304C>A
cDNA c.1735G>T
Protein p.G579W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011532085 chr4:g.152324304C>A c.1735G>T p.G579W RefSeq GRCh38/hg38
XM_011532084 chr4:g.152324304C>A c.1735G>T p.G579W RefSeq GRCh38/hg38
XM_011532083 chr4:g.152324304C>A c.1735G>T p.G579W RefSeq GRCh38/hg38
NM_033632 chr4:g.152324304C>A c.1735G>T p.G579W RefSeq GRCh38/hg38
XM_017008362 chr4:g.152324304C>A c.1735G>T p.G579W RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
FBXW7 G579W unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References