Gene Variant Detail

Gene FBXW7
Variant T15_G16insP
Impact List insertion
Protein Effect loss of function
Gene Variant Descriptions FBXW7 T15_G16insP results in the insertion of a proline (P) in the Fbxw7 protein between amino acids 15 and 16 (UniProt.org). T15_G16insP results in decreased binding of Fbxw7 to cyclinE1 and aberrant Fbxw7 localization in cell culture (PMID: 17909001).
Associated Drug Resistance

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Transcript NM_033632
gDNA chr4:g.152411760_152411761insGAG
cDNA c.45_46insCCT
Protein p.T15_G16insP
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011532083 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_017008362 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_011532085 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
NM_033632 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_011532084 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
NM_001257069 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
FBXW7 T15_G16insP loss of function mTORC1 Inhibitor
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References