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Gene | MAP2K1 |
Variant | D351G |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | MAP2K1 D351G lies within the protein kinase domain of the Map2k1 protein (UniProt.org). D351G has been identified in the scientific literature (PMID: 26582713, PMID: 24755471), but has not been biochemically characterized and therefore, its effect on Map2k1 protein function is unknown (PubMed, Feb 2022). |
Associated Drug Resistance |
Transcript | NM_002755.3 |
gDNA | chr15:g.66489747A>G |
cDNA | c.1052A>G |
Protein | p.D351G |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_002755.3 | chr15:g.66489747A>G | c.1052A>G | p.D351G | RefSeq | GRCh38/hg38 |
NM_002755 | chr15:g.66489747A>G | c.1052A>G | p.D351G | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
MAP2K1 Q56P MAP2K1 H119Y MAP2K1 D351G | colorectal cancer | predicted - sensitive | LY3214996 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, LY3214996 treatment in a colorectal cancer cell line harboring MAP2K1 Q56P, MAP2K1 H119Y, and MAP2K1 D351G led to decreased cell proliferation in culture, and inhibition of tumor growth in a cell line xenograft model (PMID: 31744895). | 31744895 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
MAP2K1 D351G | unknown | |
MAP2K1 Q56P MAP2K1 H119Y MAP2K1 D351G |