Gene Variant Detail

Gene FBXW7
Variant R465P
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FBXW7 R465P lies within the WD repeat domain of the Fbxw7 protein (UniProt.org). R465P has not been characterized, however other R465 hotspots inactivate Fbxw7, therefore, R465P is predicted to lead to a loss of function (PMID: 17646409, PMID: 17909001, PMID: 19340001).
Associated Drug Resistance

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Transcript NM_033632
gDNA chr4:g.152328232C>G
cDNA c.1394G>C
Protein p.R465P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011532085 chr4:g.152328232C>G c.1394G>C p.R465P RefSeq GRCh38/hg38
NM_033632 chr4:g.152328232C>G c.1394G>C p.R465P RefSeq GRCh38/hg38
XM_017008362 chr4:g.152328232C>G c.1394G>C p.R465P RefSeq GRCh38/hg38
XM_011532084 chr4:g.152328232C>G c.1394G>C p.R465P RefSeq GRCh38/hg38
XM_011532083 chr4:g.152328232C>G c.1394G>C p.R465P RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FBXW7 R465P loss of function - predicted mTORC1 Inhibitor
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References