Gene Variant Detail

Gene FBXW7
Variant R465Y
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FBXW7 R465Y lies within the WD repeat domain of the Fbxw7 protein (UniProt.org). R465Y has not been characterized however other R465 hotspots inactivate Fbxw7 therefore, R465Y is predicted to lead to a loss of function (PMID: 17646409, PMID: 17909001, PMID: 19340001).
Associated Drug Resistance

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Transcript NM_033632
gDNA chr4:g.152328232_152328233delCGinsTA
cDNA c.1393_1394delCGinsTA
Protein p.R465Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017008362 chr4:g.152328232_152328233delCGinsTA c.1393_1394delCGinsTA p.R465Y RefSeq GRCh38/hg38
XM_011532085 chr4:g.152328232_152328233delCGinsTA c.1393_1394delCGinsTA p.R465Y RefSeq GRCh38/hg38
NM_033632 chr4:g.152328232_152328233delCGinsTA c.1393_1394delCGinsTA p.R465Y RefSeq GRCh38/hg38
XM_011532083 chr4:g.152328232_152328233delCGinsTA c.1393_1394delCGinsTA p.R465Y RefSeq GRCh38/hg38
XM_011532084 chr4:g.152328232_152328233delCGinsTA c.1393_1394delCGinsTA p.R465Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Protein Effect Treatment Approaches
FBXW7 R465Y loss of function - predicted mTORC1 Inhibitor
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References