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Gene FBXW7
Variant S516R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FBXW7 S516R lies within WD repeat 4 of the Fbxw7 protein (UniProt.org). S516R has not been characterized in the scientific literature and therefore, its effect on Fbxw7 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 S516R

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Transcript NM_033632.3
gDNA chr4:g.152326102A>C
cDNA c.1548T>G
Protein p.S516R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_024454123.2 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
XM_011532084 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
NM_018315 chr4:g.152324252_152324253delGAinsCG c.1546_1547delTCinsCG p.S516R RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
NM_018315.5 chr4:g.152324252_152324253delTCinsCG c.1546_1547delTCinsCG p.S516R RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
XM_011532083 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
NM_033632 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
XM_017008362 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
NM_018315.4 chr4:g.152324252_152324253delTCinsCG c.1546_1547delTCinsCG p.S516R RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
XM_011532085 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152326102A>C c.1548T>G p.S516R RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References