Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
Gene | FLT3 |
Variant | V637I |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | FLT3 V637I lies within the protein kinase domain of the Flt3 protein (UniProt.org). V637I has not been characterized in the scientific literature and therefore, its effect on Flt3 protein function is unknown (PubMed, May 2024). |
Associated Drug Resistance | |
Category Variants Paths |
FLT3 mutant FLT3 exon15 FLT3 V637I |
Transcript | NM_004119.3 |
gDNA | chr13:g.28033920C>T |
cDNA | c.1909G>A |
Protein | p.V637I |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_004119.2 | chr13:g.28033920C>T | c.1909G>A | p.V637I | RefSeq | GRCh38/hg38 |
NM_004119 | chr13:g.28033920C>T | c.1909G>A | p.V637I | RefSeq | GRCh38/hg38 |
NM_004119.3 | chr13:g.28033920C>T | c.1909G>A | p.V637I | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|