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Gene | NTRK2 |
Variant | C45F |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | NTRK2 C45F lies within the LRRNT domain of the Ntrk2 protein (UniProt.org). C45F has been identified in sequencing studies (PMID: 25234657), but has not been biochemically characterized and therefore, its effect on Ntrk2 protein function is unknown (PubMed, Mar 2024). |
Associated Drug Resistance | |
Category Variants Paths |
NTRK2 mutant NTRK2 C45F |
Transcript | NM_001018064.3 |
gDNA | chr9:g.84670882G>T |
cDNA | c.134G>T |
Protein | p.C45F |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001291937.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014761.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014760.3 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001018065 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_011518718.3 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_005252001.3 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_005252001.4 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369545.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_005252004.3 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014751.2 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001018064.2 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001018064 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014756.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369534.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001291937 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369541.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001018064.3 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_011518718 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014758 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001291937.2 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014756 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001007097 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369533.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369537.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369547.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369548.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014759 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_005252004.2 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_005252003 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014753.2 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_011518720 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369544.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369542.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014757 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014754.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014757.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001018065.2 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_006180.4 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014755.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369543.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014755 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001018066.2 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014752.2 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014752.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001018066 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_005252006.4 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_006180.6 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014755.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_006180 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014754 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014760.2 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_011518720.3 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_005252003.3 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_005252003.4 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014752 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014751 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_005252006 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001018065.2 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_011518718.4 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369549.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014753.3 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_047423432.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014759.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369532.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014751.3 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_047423433.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369538.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001007097.2 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014760 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_005252007 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_005252004 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369546.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014758.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014753 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_017014761 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001007097.3 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_005252007.4 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001018066.3 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369539.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
XM_005252001 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
NM_001369540.1 | chr9:g.84670882G>T | c.134G>T | p.C45F | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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