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Gene TP53
Variant M237_S241del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions TP53 M237_S241del results in the deletion of five amino acids in the DNA-binding domain of the Tp53 protein (PMID: 22713868). M237_S241del has not been characterized in the scientific literature and therefore, its effect on Tp53 protein function is unknown (PubMed, Jun 2023).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 M237_S241del

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Transcript NM_000546.6
gDNA chr17:g.7674241_7674255del15
cDNA c.709_723del15
Protein p.M237_S241delMCNSS
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.3 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241delMCNSS RefSeq GRCh38/hg38
NM_001126115.2 chr17:g.7669672_7669686del15 c.709_723del15 p.L237_K241delLKSKK RefSeq GRCh38/hg38
NM_001276695.3 chr17:g.7673780_7673794del15 c.710_724del15 p.A237_R241delACPGR RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241del RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241delMCNSS RefSeq GRCh38/hg38
NM_001407263.1 chr17:g.7673780_7673794del15 c.710_724del15 p.A237_R241delACPGR RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241del RefSeq GRCh38/hg38
NM_001407271.1 chr17:g.7673780_7673794del15 c.710_724del15 p.A237_R241delACPGR RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241del RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241del RefSeq GRCh38/hg38
NM_001407267.1 chr17:g.7673780_7673794del15 c.710_724del15 p.A237_R241delACPGR RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241delMCNSS RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241delMCNSS RefSeq GRCh38/hg38
NM_001407269.1 chr17:g.7673780_7673794del15 c.710_724del15 p.A237_R241delACPGR RefSeq GRCh38/hg38
NM_001407265.1 chr17:g.7673780_7673794del15 c.710_724del15 p.A237_R241delACPGR RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241delMCNSS RefSeq GRCh38/hg38
NM_001276760.3 chr17:g.7673780_7673794del15 c.710_724del15 p.A237_R241delACPGR RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241delMCNSS RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241del RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241del RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241delMCNSS RefSeq GRCh38/hg38
NM_000546 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241del RefSeq GRCh38/hg38
NM_001276696.3 chr17:g.7673780_7673794del15 c.710_724del15 p.A237_R241delACPGR RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241del RefSeq GRCh38/hg38
NM_001126118.2 chr17:g.7673780_7673794del15 c.710_724del15 p.A237_R241delACPGR RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241delMCNSS RefSeq GRCh38/hg38
NM_001276761.3 chr17:g.7673780_7673794del15 c.710_724del15 p.A237_R241delACPGR RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674241_7674255del15 c.709_723del15 p.M237_S241delMCNSS RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References