Profile Response Detail

Molecular Profile MET del exon14
Therapy Crizotinib
Indication/Tumor Type lung adenocarcinoma
Response Type sensitive
Create By cstatz
Update By cstatz

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MET del exon14 lung adenocarcinoma sensitive Crizotinib Clinical Study Actionable In a clinical case study, three patients with lung adenocarcinoma harboring a deletion of MET exon 14 demonstrated partial responses when treated with Xalkori (crizotinib) (PMID: 25971939). 25971939
PubMed Id Reference Title Details
(25971939) Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping. Full reference...