Profile Response Detail

Molecular Profile TP53 loss
Therapy AZD6738 + Radiotherapy
Indication/Tumor Type colorectal cancer
Response Type sensitive
Create By cstatz
Update By cstatz

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 loss colorectal cancer sensitive AZD6738 + Radiotherapy Preclinical - Cell line xenograft Actionable In a preclinical study, AZD6738 increased sensitivity to radiotherapy in colorectal cancer xenograft models harboring a loss of TP53, resulting in a greater delay of tumor growth compared to radiation alone and an improved survival compared to control or either agent alone (PMID: 28062704). 28062704
PubMed Id Reference Title Details
(28062704) Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei. Full reference...