Profile Response Detail

Molecular Profile KRAS mutant
Therapy PF3644022 + PF-477736
Indication/Tumor Type Advanced Solid Tumor
Response Type predicted - sensitive
Create By tyin
Update By djd

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS mutant Advanced Solid Tumor predicted - sensitive PF3644022 + PF-477736 Preclinical - Cell line xenograft Actionable In a preclinical study, Chk1 inhibitor PF-477736 and MK2 inhibitor PF3644022 synergistically inhibited growth of various cancer cell lines harboring KRAS mutations in culture and in cell line xenograft models (PMID: 26140595). 26140595
PubMed Id Reference Title Details
(26140595) A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer. Full reference...