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Molecular Profile PTEN loss
Therapy BGT226
Indication/Tumor Type acute lymphoblastic leukemia
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN loss acute lymphoblastic leukemia sensitive BGT226 Preclinical - Cell culture Actionable In a preclinical study, BGT226 treatment in PTEN-deficient acute lymphoblastic leukemia cells resulted in inhibition of PI3K/Akt signaling and apoptotic activity in culture (PMID: 23705826). 23705826
PubMed Id Reference Title Details
(23705826) Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia. Full reference...