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Molecular Profile Unknown unknown
Therapy E7046
Indication/Tumor Type Advanced Solid Tumor
Response Type not applicable

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable E7046 Phase I Actionable In a Phase I trial, E7046 treatment resulted in no objective responses, only stable disease in 13% (4/30) and metabolic responses in 13% (4/30) of patients with advanced solid tumors (Ann Oncol 2017, Vol 28, Suppl 5, Abstract # 373PD; NCT02540291). detail...
Unknown unknown Advanced Solid Tumor not applicable E7046 Preclinical Actionable In a preclinical study, multiple mouse tumor models demonstrated inhibition of tumor growth when treated with E7046 (Cancer Immunol Res 2016;4(1 Suppl):Abstract nr B034). detail...
PubMed Id Reference Title Details
Abstract B034: Preclinical immune antitumor activity of myeloid-targeting E7046 and Treg depleting E7777 Full reference...
Phase 1 Study of E7046, a PGE2 Receptor EP-4 inhibitor that targets immunosuppressive myeloid cells in the tumor microenvironment Full reference...