Profile Response Detail

Molecular Profile BRCA1 mutant
Therapy Olaparib
Indication/Tumor Type Her2-receptor negative breast cancer
Response Type sensitive
Create By tyin
Update By spatt

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRCA1 mutant Her2-receptor negative breast cancer sensitive Olaparib FDA approved Actionable In a Phase III trial (OlympiAD) that supported FDA approval, Lynparza (olaparib) treatment resulted in significantly improved median progression-free survival (7.0 vs 4.2 months, HR=0.58, p<0.001) and higher response rate (59.9% vs 28.8%) compared to standard chemotherapy in ERBB2 (HER2)-negative breast cancer patients harboring a germline BRCA mutation (PMID: 28578601; NCT02000622). 28578601
PubMed Id Reference Title Details
(28578601) Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation. Full reference...