Profile Response Detail

Molecular Profile ATM del KRAS G12D
Therapy VX-970
Indication/Tumor Type lung adenocarcinoma
Response Type sensitive
Create By cstatz
Update By cstatz


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM del KRAS G12D lung adenocarcinoma sensitive VX-970 Preclinical Actionable In a preclinical study, a KRAS G12D driven lung adenocarcinoma mouse model with homozygous deletion of ATM was sensitive to VX-970, demonstrating decreased tumor volume and greater overall survival compared to control treated models (PMID: 28363999). 28363999
PubMed Id Reference Title Details
(28363999) ATM Deficiency Is Associated with Sensitivity to PARP1- and ATR Inhibitors in Lung Adenocarcinoma. Full reference...