Profile Response Detail

Molecular Profile AKT1 E17K
Therapy Capivasertib
Indication/Tumor Type lung adenocarcinoma
Response Type predicted - sensitive
Create By cstatz
Update By driscd


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
AKT1 E17K lung adenocarcinoma predicted - sensitive Capivasertib Case Reports/Case Series Actionable In a Phase I trial, a patient with lung adenocarcinoma harboring AKT1 E17K demonstrated a partial response when treated with Capivasertib (AZD5363) (PMID: 28489509; NCT01226316). 28489509
PubMed Id Reference Title Details
(28489509) AKT Inhibition in Solid Tumors With AKT1 Mutations. Full reference...