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Molecular Profile | Unknown unknown |
Therapy | G-TPP + Navitoclax |
Indication/Tumor Type | melanoma |
Response Type | not applicable |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
Unknown unknown | melanoma | not applicable | G-TPP + Navitoclax | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the mitochondrial Hsp90 inhibitor G-TPP and the broad BH3 mimetic Navitoclax (ABT-263) synergistically inhibited viability of melanoma cell lines in culture, and inhibited tumor growth in cell line xenograft models (PMID: 28522750). | 28522750 |
PubMed Id | Reference Title | Details |
---|---|---|
(28522750) | Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses. | Full reference... |