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Molecular Profile Unknown unknown
Therapy Cetuximab + Lumretuzumab
Indication/Tumor Type Advanced Solid Tumor
Response Type not applicable


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable Cetuximab + Lumretuzumab Phase Ib/II Actionable In a Phase Ib trial, treatment with the combination of Erbitux (cetuximab) and Lumretuzumab demonstrated minimal clinical efficacy in ERBB3 (HER3)-positive advanced solid tumor patients, resulting in an objective response rate of 6.1% (3/49), including two partial responses and a complete response in one patient with squamous cell carcinoma of the head and neck (PMID: 28600476). 28600476
PubMed Id Reference Title Details
(28600476) Phase Ib Study of Lumretuzumab Plus Cetuximab or Erlotinib in Solid Tumor Patients and Evaluation of HER3 and Heregulin as Potential Biomarkers of Clinical Activity. Full reference...