Profile Response Detail

Molecular Profile KRAS G12D
Therapy PD-0325901 + ZSTK474
Indication/Tumor Type colorectal cancer
Response Type sensitive
Create By cstatz
Update By cstatz


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G12D colorectal cancer sensitive PD-0325901 + ZSTK474 Preclinical - Cell line xenograft Actionable In a preclinical study, the combination treatment of PD-0325901 and ZSTK474 inhibited tumor growth of colorectal cancer cell line xenograft models harboring KRAS G12D (PMID: 28775144). 28775144
PubMed Id Reference Title Details
(28775144) A Bifunctional MAPK/PI3K Antagonist for Inhibition of Tumor Growth and Metastasis. Full reference...