Profile Response Detail


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Molecular Profile VHL mutant
Therapy Unspecified VEGFR inhibitor
Indication/Tumor Type renal cell carcinoma
Response Type no benefit


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
VHL mutant renal cell carcinoma no benefit Unspecified VEGFR inhibitor Clinical Study - Meta-analysis Actionable In a meta-analysis of 6 clinical studies, VHL mutation status was not associated with overall response rate (relative risk=1.47, p=0.20), progression-free survival (HR=1.02, p=0.91), or overall survival (HR=0.80, p=0.21) in a total of 633 patients with renal cell carcinoma who received anti-VEGF therapies (PMID: 28103578). 28103578
PubMed Id Reference Title Details
(28103578) Prognostic and predictive value of VHL gene alteration in renal cell carcinoma: a meta-analysis and review. Full reference...