Molecular Profile | Unknown unknown |
Therapy | CCT241533 + Rucaparib |
Indication/Tumor Type | colorectal cancer |
Response Type | not applicable |
Create By | cstatz |
Update By | cstatz |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References | Unknown unknown | colorectal cancer | not applicable | CCT241533 + Rucaparib | Preclinical - Cell culture | Actionable | In a preclinical study, CCT241533 enhanced the growth inhibition effect of Rubraca (rucaparib) in colorectal cancer cells in culture (PMID: 21239475). | 21239475 |
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PubMed Id | Reference Title | Details |
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(21239475) | CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. | Full reference... |