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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||Omaveloxolone||Preclinical - Cell culture||Actionable||In a preclinical study, Omaveloxolone (RTA 408) induced apoptosis and inhibited growth of several human tumor cell lines in culture (PMID: 25897966).||25897966|
|Unknown unknown||Advanced Solid Tumor||not applicable||Omaveloxolone||Phase I||Actionable||In a Phase I trial, treatment with Omaveloxolone (RTA 408) in patients with an advanced solid tumor led to a median progression-free survival of 1.5 months, an overall survival of 5.8 months, and one patient with lung cancer experienced stable disease for greater than 12 months (PMID: 28919776).||28919776|
|PubMed Id||Reference Title||Details|
|(25897966)||RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity.||Full reference...|
|(28919776)||Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors.||Full reference...|