Profile Response Detail


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Molecular Profile MAP2K1 K57E
Therapy Dabrafenib
Indication/Tumor Type melanoma
Response Type resistant


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 K57E melanoma resistant Dabrafenib Preclinical Actionable In a preclinical study, MAP2K1 (MEK1) K57E mutations restored extracellular signal-regulated kinase (ERK) activation in the presence of Tafinlar (dabrafenib) in cultured melanoma cell lines (PMID: 24463458). 24463458
PubMed Id Reference Title Details
(24463458) BRAF inhibitor resistance mechanisms in metastatic melanoma: spectrum and clinical impact. Full reference...