Profile Response Detail

Molecular Profile KRAS G12C
Therapy Afatinib
Indication/Tumor Type lung adenocarcinoma
Response Type sensitive
Create By cstatz
Update By cstatz

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G12C lung adenocarcinoma sensitive Afatinib Preclinical - Pdx Actionable In a preclinical study, a lung adenocarcinoma patient-derived xenograft (PDX) model was sensitive to treatment with Gilotrif (afatinib), demonstrating inhibition of tumor growth (PMID: 29925635). 29925635
PubMed Id Reference Title Details
(29925635) Afatinib restrains K-RAS-driven lung tumorigenesis. Full reference...