Profile Response Detail

Molecular Profile KRAS G13D
Therapy Buparlisib
Indication/Tumor Type colon cancer
Response Type no benefit
Create By stafford
Update By smockus


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G13D colon cancer no benefit Buparlisib Preclinical Actionable In a preclinical studu, BKM120 alone failed to induce tumor regression in mouse xenograft models of Kras G13D mutant colorectal cancer (PMID: 24576621). 24576621
PubMed Id Reference Title Details
(24576621) Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. Full reference...