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Molecular Profile JAK3 H583Y
Therapy Tofacitinib
Indication/Tumor Type hematologic cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
JAK3 H583Y hematologic cancer sensitive Tofacitinib Preclinical - Cell culture Actionable In a preclinical study, Xeljanz (tofacitinib, CP-690,550) decreased cell viability in transformed mouse Ba/F3 cells expressing Jak3 H538Y (PMID: 28284718). 28284718
PubMed Id Reference Title Details
(28284718) Novel JAK3-Activating Mutations in Extranodal NK/T-Cell Lymphoma, Nasal Type. Full reference...