Profile Response Detail


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Molecular Profile ALK rearrange ALK G1202R
Therapy Brigatinib
Indication/Tumor Type lung non-small cell carcinoma
Response Type predicted - resistant


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK rearrange ALK G1202R lung non-small cell carcinoma predicted - resistant Brigatinib Clinical Study - Cohort Actionable In a retrospective study, ALK G1202R was identified in 33% (23/70) of plasma samples at disease progression in ALK-positive non-small cell lung cancer patients who received second-generation ALK TKI treatment, including Alecensa (alectinib) (n=46), Zykadia (ceritinib) (n=4), Alunbrig (brigatinib) (n=3), Ensartinib (X-396) (n=1), or more than 2 lines of TKIs (n=16) (PMID: 31358542). 31358542
ALK rearrange ALK G1202R lung non-small cell carcinoma predicted - resistant Brigatinib Case Reports/Case Series Actionable In a clinical case study, Alunbrig (brigatinib) treatment resulted in progressive disease in a patient with ALK-rearranged non-small cell lung cancer refractory to Alecensa (alectinib) treatment, ALK G1202R was identified in post-brigatinib biopsy (PMID: 29935304). 29935304
PubMed Id Reference Title Details
(29935304) Brigatinib in Patients With Alectinib-Refractory ALK-Positive NSCLC. Full reference...
(31358542) Treatment with Next-Generation ALK Inhibitors Fuels Plasma ALK Mutation Diversity. Full reference...