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Molecular Profile IDH1 wild-type PTEN mut
Therapy Pembrolizumab
Indication/Tumor Type glioblastoma
Response Type resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 wild-type PTEN mut glioblastoma resistant Pembrolizumab Clinical Study - Cohort Actionable In a retrospective analysis, PTEN mutations were significantly enriched in patients with IDH1 wild-type glioblastoma who did not respond to anti-PD-1 therapy, with either Keytruda (pembrolizumab) or Opdivo (nivolumab), compared to those who responded (odds ratio=0.85, p=0.0063), with 23 PTEN mutations identified in 32 non-responders and 3 in 13 responders (PMID: 30742119). 30742119
PubMed Id Reference Title Details
(30742119) Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma. Full reference...