Profile Response Detail


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Molecular Profile CD274 positive
Therapy Atezolizumab + Nab-paclitaxel
Indication/Tumor Type triple-receptor negative breast cancer
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 positive triple-receptor negative breast cancer sensitive Atezolizumab + Nab-paclitaxel Phase III Actionable In a Phase III trial (IMpassion130), Tecentriq (atezolizumab) in combination with Abraxane (nab-paclitaxel) resulted in improved progression-free survival (7.5 vs 5.0 months, HR=0.62, p<0.001) and overall survival (25.0 vs 15.5 months, HR=0.62) compared to placebo in patients with CD274 (PD-L1)-positive (>1%), advanced triple-receptor negative breast cancer (PMID: 30345906; NCT02425891). detail... 30345906 detail...
CD274 positive triple-receptor negative breast cancer sensitive Atezolizumab + Nab-paclitaxel Guideline Actionable The combination of Tecentriq (atezolizumab) and Abraxane (nab-paclitaxel) is included in guidelines as first line therapy for CD274 (PD-L1)-positive patients with triple-negative breast cancer (PMID: 34678411; 34678411 detail...
PubMed Id Reference Title Details
(30345906) Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer. Full reference...
ESMO Clinical Practice Guidelines Full reference...
Full reference...
Tecentriq (atezolizumab) FDA Drug Label Full reference...
(34678411) ESMO Clinical Practice Guideline for the diagnosis, staging and treatment of patients with metastatic breast cancer. Full reference...