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Molecular Profile PIK3CA wild-type PTEN pos
Therapy Cetuximab + Cisplatin
Indication/Tumor Type head and neck squamous cell carcinoma
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA wild-type PTEN pos head and neck squamous cell carcinoma predicted - sensitive Cetuximab + Cisplatin Clinical Study - Cohort Actionable In a clinical study, combination of Erbitux (cetuximab) with Platinol (cisplatin) tended to improve progression-free survival compared to placebo in PTEN-expressing, PIK3CA wild-type head and neck squamous cell carcinoma patients (HR=0.54, p=0.0502) by multivariable analysis, but not in PTEN null or PIK3CA mutated patients (HR=0.76, p=0.54) (PMID: 30926065). 30926065
PubMed Id Reference Title Details
(30926065) PTEN loss is associated with resistance to cetuximab in patients with head and neck squamous cell carcinoma. Full reference...