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|Molecular Profile||MDM2 amp|
|Therapy||unspecified MDM2 inhibitor|
|Response Type||predicted - sensitive|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|MDM2 amp||liposarcoma||predicted - sensitive||unspecified MDM2 inhibitor||Phase I||Actionable||In a Phase I trial, treatment with an unspecified MDM2 inhibitor resulted in clinical efficacy in six patients with liposarcoma harboring MDM2 amplification, including three patients with a partial response and two patients with stable disease for 15.7 months and 4.7 months (PMID: 30237864).||30237864|
|PubMed Id||Reference Title||Details|
|(30237864)||Prevalence of MDM2 amplification and coalterations in 523 advanced cancer patients in the MD Anderson phase 1 clinic.||Full reference...|