Profile Response Detail


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Molecular Profile Unknown unknown
Therapy Lenvatinib + Pembrolizumab
Indication/Tumor Type endometrial carcinoma
Response Type not applicable


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown endometrial carcinoma not applicable Lenvatinib + Pembrolizumab FDA approved Actionable In a Phase II trial (Study 111/KEYNOTE-146) that supported FDA approval, Lenvima (lenvatinib) and Keytruda (pembrolizumab) combination treatment resulted in an objective response rate of 35.6% (16/45) in patients with endometrial carcinoma that was not MSI-H or dMMR (PMID: 30922731; NCT02501096). detail... detail... 30922731
PubMed Id Reference Title Details
Keytruda (pembrolizumab) FDA Drug Label Full reference...
Lenvima (lenvatinib) FDA Drug Label Full reference...
(30922731) Lenvatinib plus pembrolizumab in patients with advanced endometrial cancer: an interim analysis of a multicentre, open-label, single-arm, phase 2 trial. Full reference...