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Molecular Profile Unknown unknown
Therapy Alisertib + Docetaxel
Indication/Tumor Type triple-receptor negative breast cancer
Response Type not applicable

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown triple-receptor negative breast cancer not applicable Alisertib + Docetaxel Preclinical - Pdx & cell culture Actionable In a preclinical study, Alisertib (MLN8237) showed additive and synergistic antitumor activity with Taxotere (docetaxel) in primary tumor and cell line xenograft models of triple-negative breast cancer, resulting in tumor regression (PMID: 24980948). 24980948
PubMed Id Reference Title Details
(24980948) Translational exposure-efficacy modeling to optimize the dose and schedule of taxanes combined with the investigational Aurora A kinase inhibitor MLN8237 (alisertib). Full reference...