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Molecular Profile | ATRX S458* |
Therapy | Adavosertib |
Indication/Tumor Type | high grade glioma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ATRX S458* | high grade glioma | sensitive | Adavosertib | Preclinical - Patient cell culture | Actionable | In a preclinical study, Adavosertib (MK-1775) inhibited growth of patient-derived glioma cells harboring ATRX S458* in culture (PMID: 31551363). | 31551363 |
PubMed Id | Reference Title | Details |
---|---|---|
(31551363) | Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX-Mutant Cancers to WEE1 Inhibition. | Full reference... |