Profile Response Detail


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Molecular Profile Unknown unknown
Therapy Sacituzumab govitecan-hziy
Indication/Tumor Type triple-receptor negative breast cancer
Response Type not applicable


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown triple-receptor negative breast cancer not applicable Sacituzumab govitecan-hziy Case Reports/Case Series Actionable In a Phase I/II trial (IMMU-132-01), Trodelvy (sacituzumab govitecan-hziy) treatment resulted in a partial response in a patient with triple-negative breast cancer (PMID: 25944802; NCT01631552). 25944802
Unknown unknown triple-receptor negative breast cancer not applicable Sacituzumab govitecan-hziy FDA approved Actionable In a Phase I/II trial (IMMU-132-01) that supported FDA approval, Trodelvy (sacituzumab govitecan-hziy) treatment resulted in an objective response rate of 33.3% (36/108, 3 complete response, 33 partial response) and a clinical benefit rate of 45.4% in patients with metastatic triple-negative breast cancer who received two or more prior therapies, with a median duration of response, progression-free survival, and overall survival of 7.7, 5.5, and 13.0 months respectively (PMID: 30786188; NCT01631552). 30786188 detail...
PubMed Id Reference Title Details
(25944802) First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors. Full reference...
Trodelvy (sacituzumab govitecan-hziy) FDA Drug Label Full reference...
(30786188) Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer. Full reference...